a Record control number WOS:000278127100002

a ISSN 0803-7051

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WG 100

b Item number .T44 2010

a Personal name Kabakci, Giray.

h Medium Electronic Document

a Title The Efficacy And Safety Of Irbesartan In Primary Hypertension Even If A Dose Is Missed: Results From The No Problem Study

c Statement of responsibility, etc Giray Kabakci, Baris Ergun Kaya, Erol Tulumen, Ugur Kocabas, Gulcan Abali, Onur Deveci, Kudret Aytemir, Lale Tokgozoglu, Hilmi Ozkutlu.

a Place of publication, distribution, etc Taylor & Francis As.,

c Date of publication, distribution, etc 2010.

a Summary, etc Objectives. This study aimed to demonstrate that irbesartan is successful in reducing diastolic blood pressure (BP) even following a missed dose after 6-8-weeks' treatment as measured by 24-hour ambulatory BP monitoring (ABPM). Methods. Eighty-eight patients (64 females, mean age: 53.4 +/- 10.6 years) with primary hypertension were included in this national, single-center, single-arm, open-label, prospective clinical study. Irbesartan (150 or 300 mg/day) was administered for 8 weeks. All patients were asked to cease treatment for l day during weeks 6-8. Changes in diastolic and mean 24-hour BP on the day of cessation and diastolic BP values during visits were efficacy parameters. Adverse events were also recorded.Resuhs. Systolic, diastolic, and mean BP values measured via ABPM before and on the day of a missed dose did not differ significantly. Irbesartan effectively controlled BP of the patients. BP normalization rates were 54% For 150 mg/day irbesartan only and 77% for both doses (150 or 300 mg/day) of irbesartan. None of the patients experienced serious adverse events throughout the study period. Conclusions. Irbesartan is successful and safe in the control of BP levels even following a missed dose at the end of a 6-8-week treatment period.

a Topical term or geographic name as entry element Cardiovascular system

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Ambulatory blood pressure measurement

a Topical term or geographic name as entry element Hypertension

a Topical term or geographic name as entry element İrbesartan

a Topical term or geographic name as entry element Blood-Pressure Control

a Topical term or geographic name as entry element Missed dose

g Relationship information FEB 2010, Vol 19 Issue 5-9, Supplement: 1

x International Standard Serial Number 08037051

t Title Blood Pressure

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3109/08037050903444099